DEVELOPMENTAL CHANGES IN α-ADRENERGIC AND MUSCARINIC RECEPTOR-MEDIATED CONTRACTIONS OF RAT VAS DEFERENS
نویسندگان
چکیده
منابع مشابه
Developmental changes in alpha-adrenergic and muscarinic receptor-mediated contractions of rat vas deferens.
Studies were made on developmental changes in phasic contractions of isolated rat vas deferens in response to norepinephrine (NE) and acetylcholine (ACh), which are mediated by alpha-adrenergic and muscarinic cholinergic receptors (alpha-R and m-R). The ED50 values of both contractions were almost constant during development, but the maximum responses to NE and ACh per wet weight and the relati...
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Regulation of the supersensitivity and subsensitivity of the alpha adrenergic (alpha-Ad) system of rat vas deferens cultured under various experimental conditions was investigated. Muscles cultured for 3 days in normal medium (Eagle's MEM) exhibited marked increase in maximal contraction to noradrenaline (NA) and high K+ (154 mM), while muscles cultured with NA (100 microM) were subsensitive to...
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The effects of the cAMP pathway on the Ca2+ response elicited by phospholipase C-coupled receptor stimulations were studied in rat parotid cells. Although 1 μM isoproterenol (Iso) itself had no effect on the cytosolic Ca2+ concentration, the pretreatment with Iso potentiated Ca2+ responses evoked by phenylephrine. The potentiating effect of Iso was attributed to a shifting of the concentration-...
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D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits alpha1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 microg/mL), oleic (100 microg/mL), laur...
متن کاملThe adrenergic and cholinergic innervation of the chicken vas deferens.
The morphological characteristics of adrenergic and cholinergic innervation are described in the vas deferens of the domestic fowl. Adrenergic innervation was much better developed than the cholinergic. Both types of nerve fibre were found in the muscular membrane, submucosal membrane and in the mucosa. The largest number of adrenergic nerve fibres was observed in the muscular membrane. These w...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)52645-2